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KMID : 0644120120250040001
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Journal of Oriental Gynecology
2012 Volume.25 No. 4 p.1 ~ p.11
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Effects of Cuscutae Semen Extract on Prevention of Osteoporosis in Ovariectomized Rats
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Kim Jong-Hyun
Kim Ho-Seok
Jun Jae-Yun
Jeong Da-Won
Cho Chang-Young
Sohn Young-Joo
Jung Hyuk-Sang
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Abstract
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Objectives : Osteoporosis, which occurs after menopause, is a kind of metabolic bone disorder. It develops when the bone mass begins to decrease radically, and its main symptoms are bone fracture and height-shortening. This thesis aims at what effects the Cuscutae Semen Extract(CSE) has on the prevention of osteoporosis in SD-rat that is caused by ovariectomy.
Methods : The 24 female white rats, after removing their ovaries, were divided into the Normals, the Control group, and the CSE administrated group. For the next 8 weeks, distilled water to the normals and the control, and the CSE(45.9 mg/100 g) to the CSE administrated group were given in the mouths of them. After 8 weeks the rats were sacrificed. Weight, albumin, aspartate aminotransferase, alanine aminotransferase, total-cholesterol, triglyceride, phosphorus, calcium, tetraiodothyronine, estradiol, the weight of the femur, the amount of tibia ash, the area of trabecular bone, and the thickness of trabecular bone were measured.
Results : The serum analysis shows that the calcium and phosphorous of the CSE administrated group significantly increased compared to that of the control group.Aspartate aminotransferase, alkalinephosphatase, total cholesterol, tetraiodothyronine of CSE group were decreased, but not so significant. Albumin, alanine aminotransferase, triglyceride and estradiol of the group showed the tendency to increase, but the significance wasn’t admitted. Regarding the variation of bone, the femur weight and the ash content of tibia, CSE group was more increased than the control group but the significance wasn’t admitted. The histological observation shows that the trabecular thickness was more increased than the control group, and trabecular area increased significantly compared to those of the control group. The number of osteoclast and osteoblast area of the CSE groups decreased significantly compared to those of the
control group.
Conclusions : From the result of the above study, CSE should be effective for the osteoporosis cure and precaution and deeper study through bedside and clinical demonstration is much needed from now on.
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KEYWORD
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Osteoporosis, Ovariectomized rat, Cuscutae Semen Extract, Trabecular, Osteoclast
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